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KMID : 0861120080120030035
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Korean Journal of Oriental Preventive Medicine
2008 Volume.12 No. 3 p.35 ~ p.45
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Sibjeondaebotang and Yugmijihwangtang’s Toxicological Effects on Rat’s Fetus
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Han Sang-Baek
Jeon Seong-Jin
Shin Heon-Tae
Park Hae-Mo
Lee Sun-Dong
Park Cheol-Soo
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Abstract
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Purpose : To evaluate safety of Sibjeondaebotang and Yugmijihwangtang in rats’ fetus
Methods : Female Sprague-Dawley rats were orally administered with the Sibjeondaebotang and Yugmijihwangtang at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. To observe skeletal malformations, fetuses were stained with alcian blue and alizarin red S.
Results : Neonatal body weight and number of fetus of Sibjeondaebotang, Yugmijihwangtang group were increased to those of control group. The fetuses treated with Sibjeondaebotang, Yugmijihwangtang didn’t showed external malformation. Vertebral and sternal skeletal variations were observed in Sibjeondaebotang, Yugmijihwangtang administered group, but compared to the control, those skeletal variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumbar, sacral and caudal vertebrae
Conclusion : From these results, it can be concluded that Sibjeondaebotang, Yugmijihwangtang shows no toxicity effects on fetus body weight and number of live fetuses. Although skeletal variations were shown in vertebrate and sternum, Sibjeondaebotang, Yugmijihwangtang did not show significant changes in bone malformation.
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KEYWORD
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Sibjeondaebotang, Yugmijihwangtang, Fetus, herbal medicine, variation, skeletal malformation
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